hereditary disease that causes degeneration of cerebral cortex and basal ganglia.
Involves disturbance in neurotransmitter substance primarily
> Gamma Aminobyutric Acid (GABA)
> Dopamine
GABA neurons in basal ganglia, frontal cortex and cerebellum are destroyed
GABA neurotransmitter production Excess of dopamine causes abnormal nerotransmisson along
the affected pathway
Chorea and mental deterioration
Enlargement of the ventricles in HD patients due to atrophy of
the head of the caudate from neuronal loss.
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